Interstates & Highways

From Miami to New York, We've Got You Covered

Our region is equipped with 600 miles of state and federal highways providing quick and low-cost access to domestic markets and world-class international centers of commerce.

We are situated halfway between Miami and New York City at the junction of Interstate 95 and 20, putting the region within eight hours drive time of more than half of the population of the United States. Major cities like Charlotte, Charleston, and Greenville are within a three-hour drive.

Several major Interstates (I-95, I-20, I-73, I-26, and I-77) and U.S. Highways (17, 378, 52, 521, 701, 301, 1 and 501) run throughout our region



Interstate 95: The main north-south interstate highway along the East Coast. I-95 connects southern Florida to upper New England, serving major metropolitan areas like Miami, Washington D.C., Baltimore, New York, and Boston.


Interstate 20: A major east-west interstate highway that connects the Southeastern United States. I-20 begins in the heart of the NESA region at I-95 and travels to Kent, TX., serving cities like Dallas/Fort Worth, Tuscaloosa, and Atlanta. 


Interstate 73: Part of a planned corridor that will traverse the NESA region. Once the scheduled projects are completed, I-73 will connect Myrtle Beach directly to Michigan, serving cities like Greensboro, Roanoke, and Columbus.


Interstate 26: Accessible within 45 minutes of the NESA region. I-26 is the primary highway that provides access to Charleston, home to one of the East Coast's largest deepwater ports. 


 ​​​​​Interstate 77: Accessible within 45 minutes of the NESA region. I-77 begins in Columbia and connects directly to Cleveland and provides quick and easy access to Charlotte, N.C.


Getting Your Products Where They Need To Go

Over 9 million tons of freight move through our region's vast railroad network each year. There are over 350 miles of rail throughout the region, including short line railroads and Class I tracks serviced by CSX Transportation, which serves the new Inland Port Dillon and connects our region directly to the Port of Charleston and numerous other freight outlets. Short line track operators such as R.J. Corman Railroad Group, South Carolina Central Central Railroad, Genesee & Wyominig, and Aberdeen & Rockfish also serve the region. Many sites in our region are rail-served, with direct access to the railway system.



CSX: The CSX network reaches nearly two–thirds of the nation’s population. Our region is home to a CSX regional headquarters and the largest CSX rail yard in the state of South Carolina.  


Shipping Made Easy

Not only does our region have direct access to major domestic markets, our close proximity to major ports extends our reach to the rest of the world. The NESA region is located just north of the Port of Charleston, one of the largest ports in the United States. Our newest asset, Inland Port Dillon, along with our extensive highway and railway networks minimizes travel times to the Port of Charleston, along with the Port of Wilmington and the Port of Savannah.

Inland Port Dillon, which is located within the Carolina I-95 Mega Site in Dillon County, offers overnight access to and from the Port of Charleston via Class I CSX track.



South Carolina Ports: The Port of Charleston is one of the largest ports on the East Coast. They utilize five terminals (3 container, 2 break-bulk) to handle more than $75 Billion in goods annually and is the most productive port in the U.S. Our region's newest addition, Inland Port Dillon provides direct rail services to the Port of Charleston. They also operate a break-bulk port in our region out of Georgetown County.


North Carolina Ports: Located within 2 hours of the region's center, the Port of Wilmington offers terminal facilities serving container, bulk, breakbulk, and ro-ro operations. CSX Transportation also provides intermodal rail services. 


Georgia Ports: The Port of Savannah, located within a 3-hour drive from the region's center, is the second busiest U.S. container exporter. Rail services are provided by CSX Transportation. 


Convenient Travel To Anywhere In The World

Two airports are located in our region, Florence Regional Airport and Myrtle Beach International Airport. The NESA region is also close to the major commercial airports Charleston International, Charlotte Douglas International, and Columbia Metropolitan.





Florence Regional Airport: Offers flights to and from Charlotte Douglas International Airport, which takes about 30 minutes. 


Myrtle Beach International Airport: Serving 1.7 million passengers annually, Myrtle Beach International is the third-busiest airport in South Carolina and is categorized by the FAA as a small-hub primary commercial service facility. 


Charleston International Airport: Accessible within 2 hours of the region's center, Charleston International is South Carolina's busiest airport. It is home to the Boeing facility that assembles the 787 Dreamliner. 


Charlotte Douglas International Airport: The fifth largest airport in the United States can be reached within a two and a half hour drive from the NESA region. With over 700 daily departures, Charlotte Douglas International provides flights to more than 170 destinations worldwide.


Columbia Metropolitan Airport: Home to the UPS southeastern air hub, Columbia Metropolitan, which is within a 90-minute drive from the region's center, provides flights to major cities like New York, Dallas, and Atlanta. 

North Eastern Strategic Alliance

P.O. Box 100547
Florence, South Carolina, USA 29502


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